John Wayne Casserole is an easy ground beef casserole that is filled with flavor! It has a biscuit base and is loaded with diced tomatoes, onions, cheese, sour cream, taco seasoning, and more cheese! This is one of our favorite easy ground beef casseroles to make for dinner.
This is truly one of our favorite ground beef comfort food dinners. When I have hamburger ground beef in the fridge that I need to use this is the recipe I work on. I love that you can customize it based on what you have in the house.
This John Wayne casserole is similar to a beef fajita but in casserole form. I change up what I put in this casserole based on what we have available. This is one of those beef casserole dishes you can easily change based on what you and your family enjoys.
I love that it has a Bisquick baking mix base that turns out amazing. It is amazing all of the things you can make with Bisquick Mix. We have been making Bisquick Waffles, Bisquick Peach Cobbler, Pancake Muffins, and Bisquick beer bread just to name a few things.
We started buying giant boxes of Bisquick from Costco we have been using it so much. It is so versatile and always tastes amazing.
Ingredients
Ground Beef - You can easily change this from ground beef to ground turkey, ground chicken, or a meat alternative like Beyond Beef.
Taco Seasoning - I use 1 regular taco seasoning mix from the grocery store.
Rotel Diced Tomatoes and Green Chilies - I used a mild version of Rotel but you can easily use spicy or other versions.
Bisquick Baking Mix - You can easily use gluten-free Bisquick if you are gluten intolerant.
Cheddar cheese - feel free to change out the cheddar cheese for Colby jack, mozzarella, or any mix of cheeses.
Onions - I didn't add onions into the recipe because I ran out. You can easily add in a cup of diced onions and cook the onions with the ground beef so they are soft.
Equipment needed
Frying Pan
Mixing bowl
Hamburger Chopper - I love to use the hamburger mix and chop to break up ground beef while it is cooking. I honestly use this tool with a ton of recipes. It is one of my most used kitchen tools.
9 X 13 inch baking dish
Heat resistant potholders - A couple of years ago we had a fire scare when we didn't realize we had turned a burner on and a cloth potholder caught fire. Thankfully we walked by the kitchen and saw the smoke and were able to get it out ourselves. Since then we have only used these heat-resistant potholders.
Nonstick cooking spray - I use nonstick spray on the casserole dish to make it easier to serve and also on my hands when I am pushing the Bisquick dough into the casserole dish.
Recipe Tips
Don't forget to preheat the oven.
You can add in extra green chilies if you would like this dish to be spicier. I serve it to my husband's mom and know that I will get a ton of side-eye if I make it too spicy.
Feel free to add in diced red peppers
If you don't have biscuit mix you can easily make this with Pillsbury Grands biscuits spread on the bottom of the baking dish. Just make sure to push them together so they fill the pan. You will want to bake them for half their normal baking time to get them set in the bottom of the casserole dish before adding in the beef mixture.
I highly suggest putting a baking sheet under your casserole dish in the oven. When the Bisquick dough bakes it pushes the other ingredients higher and higher in the dish and some of the toppings and/or casserole juices may spill over the side.
Allow the John Wayne Casserole to sit for a few minutes before serving.
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