If familiarity does indeed breed contempt, then Napoli and Liverpool's latest meeting could well be a feisty affair.
The two sides are set for their fifth clash since 2018 after being paired again in the group stages of the Champions League.
Napoli head into the game second in Serie A after an impressive opening period of the season, while Liverpool's patchy start continued over the weekend with a goalless draw at Everton.
But, regardless of form, both teams will be desperate to earn a win that would likely set either up to top a fascinating group also featuring Rangers and Ajax.
The Sporting News is following the match live and providing live score updates and commentary.
MORE: Everton vs. Liverpool result, highlights: Honours even in entertaining goalless Merseyside derby
Goals:
120 mins from kickoff:
Napoli announced that Victor Osimhen has trained separately from the rest of their squad because of a muscle issue, making the striker, who has scored twice and set up another during the opening weeks of the season, a doubt.
Midfielder Diego Demme is out and winger Hirving Lozano has also trained on his own after having an examination that ruled out facial fractures following his departure on a stretcher during the 2-1 win at Lazio on Saturday.
Napoli predicted lineup (4-2-3-1): Meret (GK) - Di Lorenzo, Rrahmani, Kim, Rui - Anguissa, Lobotka - Zielinski, Politano, Kvaratskhelia - Raspadori
Liverpool have issues in midfield, where Jordan Henderson missed the Everton match with a hamstring injury and Fabio Carvalho is a doubt because of a dead leg.
Naby Keita and Alex Oxlade-Chamberlain will be sidelined "for a while" because of muscle injuries, Klopp said before that game, and Thiago Alcantara was due to resume training on Monday, making him unlikely to be ready for Napoli after suffering a problem at Fulham during the first game of Liverpool's season.
Goalkeeper Caoimhin Kelleher and defenders Ibrahima Konate and Calvin Ramsay are still out.
Liverpool predicted lineup (4-3-3): Alisson (GK) - Alexander-Arnold, Matip, Van Dijk, Robertson - Arthur, Fabinho, Milner - Salah, Nunez, Jota
Napoli play host to Liverpool in Naples, Italy. It kicks off at 20:00 BST on Saturday, September 3.
UK: BT Sport will be showing the match live on TV and online/via the BT Sport app.
USA: CBS streams every match on Paramount+, with select matches televised on CBS or CBS Sports Network. Univision places select matches across its TV networks (Univision, TUDN, UniMas, and Galavision) and also makes all matches from the group stage on available via its ViX streaming platform. Any matches televised by either CBS or Univision can also be streamed on fuboTV.
Canada: Every Champions League game streams live on DAZN.
Australia: Fans can watch the action via Stan Sport.