Giants vs. Rockies odds, line: 2021 MLB picks, May 5 predictions from proven computer model

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Oct 4, 2019; Los Angeles, CA, USA; Washington Nationals pitcher Max Scherzer (31) throws in relief in the 8th inning against the Los Angeles Dodgers in game two of the 2019 NLDS playoff baseball series at Dodger Stadium. Photo by Robert Hanashiro, USA TODAY Staff

After splitting a doubleheader on Tuesday, the San Francisco Giants and host Colorado Rockies meet to decide which team wins the three-game series in a key National League West Division matchup on Wednesday. The Giants (18-12), first in the division, have won six of eight from Colorado this season. The Rockies (11-19), fifth in the division, have lost two of three and five of seven. San Francisco beat Colorado 12-4 in Game 1 before Charlie Blackmon hit a three-run home run to cap a six-run rally in the bottom of the seventh for an 8-6 Rockies win in the nightcap on Tuesday.

First pitch from Coors Field in Denver is set for 3:10 p.m. ET. The Giants lead the all-time series 256-214, although the Rockies hold a 129-103 edge in games played at Denver. Both teams are -105 on the money line (risk $105 to win $100) in the latest Giants vs. Rockies odds from William Hill Sportsbook, while the over-under for total runs scored is 10. Before making any Rockies vs. Giants picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a profitable start in 2021, going 36-28 on top-rated MLB money-line picks through five weeks, returning almost $400. Anyone following it has seen huge rewards. 

Now, the model has dialed in on Giants vs. Rockies. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Rockies vs. Giants:

• Giants vs. Rockies money line: San Francisco -105, Colorado -105
• Giants vs. Rockies run line: Colorado -1.5 (-170)
• Giants vs. Rockies over-under: 10 runs
• SF: Is 6-1 in its last seven Wednesday games
• COL: Is 4-1 in its last five home games vs. a right-handed starter

Why you should back the Rockies

Colorado will send right-hander Jon Gray (3-2, 3.15 ERA) to the mound. Gray is 3-0 and has a 1.85 ERA in four starts at Coors Field this season. In his last start on Friday at Arizona, Gray was touched up for five runs, including four earned, in six innings. He walked one and struck out three. In six starts on the year, he has allowed 27 hits, 12 earned runs, while walking 14 and striking out 30.

Offensively, the Rockies are led by left fielder Raimel Tapia, who has a five-game hitting streak. He is 10-for-20 (.500) with a homer and seven RBIs during that span. For the season, Tapia is hitting .314 with three homers and 13 RBIs. In 50 career games against the Giants, Tapia is batting .285 with two homers and 15 RBIs.

Why you should back the Giants

Right-hander Logan Webb (1-2, 4.13 ERA) takes the hill for San Francisco. He has been solid this season, despite a record of 0-2 on the road. In his last outing, Webb took the loss at San Diego despite scattering seven hits and three earned runs over six innings. He walked one and struck out four. In the previous start against Miami, he shut the Marlins out on just three hits over seven innings. He walked three and struck out eight. In three career starts against Colorado, he is 2-0 with a 4.35 ERA with five walks and 16 strikeouts.

Catcher Buster Posey has been red hot and enters the game with a five-game hitting streak, going 13-for-21 (.619) with two doubles, three homers and six RBIs during that stretch. On Tuesday against the Rockies, Posey was 3-for-4 with a solo home run. In 150 career games against Colorado, Posey is hitting .345 with 32 doubles, three triples, 28 homers and 106 RBIs. He has a .421 on-base percentage and .570 slugging percentage.

How to make Rockies vs. Giants picks

SportsLine's model is leaning over on the total, as the teams combine for 10.8 runs in the simulations, and it also says one side of the money line has all the value. You can only see the pick at SportsLine. 

So who wins Rockies vs. Giants? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that returned more than $1,400 in 2019.