Arsenal were dealt a double defensive injury blow on Thursday night with Kieran Tierney and Pablo Mari both missing the Premier League clash against Crystal Palace.
Tierney and Mari have both been in excellent form during Arsenal's recent revival, but Mikel Arteta was forced to leave the duo out of his squad for the visit of London rivals Palace.
Mari has a tight calf, while Tierney has muscle tightness and has been left out as a precaution by Arteta.
In their place, Ainsley Maitland-Niles starts at left-back, with David Luiz coming in at centre-back alongside Rob Holding.
Despite that defensive setback, Gabriel Magalhaes returns after a period of self-isolation and is on the bench, while Thomas Partey is back from a thigh injury and takes his place among the substitutes.
Arsenal XI: Leno, Bellerin, Holding, Luiz, Maitland-Niles, Ceballos, Xhaka, Saka, Smith-Rowe, Aubameyang, Lacazette
Subs: Gabriel, Willian, Runarsson, Cedric, Partey, Pepe, Chambers, Willock, Nketiah