© Provided by Daily MailMailOnline logo
No Edinson Cavani and no Anthony Martial, so I expect we'll see Ole Gunnar Solskjaer use Marcus Rashford and Mason Greenwood as twin strikers.
With Bruno Fernandes behind them, that isn't the worst injury-induced line-up. Needing only a draw to qualify, I'm backing Manchester United to at least get a goal at the Red Bull Arena.
RB Leipzig know all about Rashford from the way he destroyed them from the bench in the reverse fixture at Old Trafford. He was introduced in the 63rd minute and had a hat-trick by full-time.
© Provided by Daily MailMino Raiola dropped the bombshell that Paul Pogba (centre) will leave Manchester United
© Provided by Daily MailRaiola's announcement about Pogba lacked class on the eve of United's crunch European clash
But this is a very big night for Greenwood. The 19-year-old opened the scoring in that 5-0 demolition in October. He burst between two Leipzig central defenders and found the far corner with a first-time, left-footed finish. That's his big strength. One chance and he can do damage.
Gallery: Porto vs Man City in UEFA Champions League action - pictures (Manchester Evening News)
His finish against West Ham at the weekend was instinctive, too, and Greenwood has to grab the bull by the horns against Leipzig.
He's lost some form this season, with Solskjaer having had to answer questions about off-field issues at times, but what an opportunity for him.
© Provided by Daily MailStriker Mason Greenwood has a huge night ahead of him against RB Leipzig on Tuesday
It was remarkable to read quotes from Paul Pogba's agent Mino Raiola on the eve of this season-defining clash, declaring his client's United career over.
What a time to drop a bombshell when Solskjaer would want all of Pogba's focus on the task at hand. It lacked class, and I hope we see a commanding performance from the Frenchman in midfield on Tuesday night.
This is going to be such a test. Leipzig are no fools. They've won all five of their Bundesliga home games this season. They held Bayern Munich to a 3-3 draw at the Allianz Arena at the weekend.
A dismal away day at Istanbul Basaksehir left United in this precarious position in Group H. Now they must stand up to the challenge.
© Provided by Daily MailOle Gunnar Solskjaer's side have it all to do to reach the Champions League knockout stage
Read more